Posthemorrhagic hydrocephalus development after germinal matrix hemorrhage: Established mechanisms and proposed pathways
نویسندگان
چکیده
منابع مشابه
Targeting Germinal Matrix Hemorrhage–Induced Overexpression of Sodium‐Coupled Bicarbonate Exchanger Reduces Posthemorrhagic Hydrocephalus Formation in Neonatal Rats
BACKGROUND Germinal matrix hemorrhage (GMH) is a leading cause of mortality and lifelong morbidity in preterm infants. Posthemorrhagic hydrocephalus (PHH) is a common complication of GMH. A sodium-coupled bicarbonate exchanger (NCBE) encoded by solute carrier family 4 member 10 gene is expressed on the choroid plexus basolateral membrane and may play a role in cerebrospinal fluid production and...
متن کاملBiomarkers in Neonatal Posthemorrhagic Hydrocephalus
Posthemorrhagic hydrocephalus (PHH) is a rare but serious outcome among premature babies in the NICU, with consequences including mortality and severe neurodevelopmental disabilities. The causes of PHH are still not entirely understood, and its prevention and treatment are controversial. Various cerebrospinal fluid biomarkers have been studied in infants with PHH in order to recognize the cause...
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Germinal matrix–intraventricular hemorrhage (GMH-IVH) is a common and characteristic form of intracranial hemorrhage occurring in the premature infant. The hemorrhage originates in small blood vessels in the subependymal germinal matrix (also termed the ganglionic eminence) and may disrupt the ependymal lining and extend into the lateral ventricle. Severe IVH consists of large amounts of intrav...
متن کاملGerminal matrix hemorrhage-intraventricular hemorrhage: pathogenesis and outcomes
Germinal matrix hemorrhage-intraventricular hemorrhage (GMH-IVH) is one of the CNS injuries affecting preterm infants occurring in about 15%–20% of subjects weighing less than 1500 g. Currently, using ultrasonography, we recognize three grades of GMH-IVH. Grade I involving the subependymal parenchyma and/or extending in less than 10% of the ventricle, grade II with intraventricular bleeding not...
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This issue of Stroke includes an important discussion of acute hydrocephalus after subarachnoid hemorrhage (SAH), contributed by a group of investigators from The Netherlands who have made several important recent contributions to our understanding of the pathophysiology of SAH. The data of Hasan et al, derived from a careful study of 473 consecutive patients with SAH admitted within 72 hours a...
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ژورنال
عنوان ژورنال: Journal of Neuroscience Research
سال: 2019
ISSN: 0360-4012
DOI: 10.1002/jnr.24394